책임운영기관 농촌진흥청 국립축산과학원 (로고)

The present study was conducted to evaluate the effects of dietary mangosteen peel extract (MPE) on growth performance, serum biochemistry, jejunum morphology, and cytokine levels in growing pigs raised at a high stocking density. A total of 120 male growing pigs (43.68 ± 0.48 kg) were randomly arranged in a 2 × 2 factorial design with stocking density (high; HD, 0.55 m2/pig and normal; ND, 0.82 m2/pig) and dietary MPE (0 or 5 g/kg) as factors. Each treatment had six replicates with four or six pigs per treatment. Feed and water were provided ad libitum for 6 weeks. The HD group exhibited lower final body weight, average daily gain, and average daily feed than the ND group (p < 0.05). None of the factors affected villus height to crypt depth ratio. Dietary MPE, but not stocking density, increased IL-10 levels in the serum com-pared to the non-supplemented control diet (p < 0.05). In the microbiome analysis, alpha diversity analysis showed significant reductions in the MPE-treated group only under normal density conditions. High density stress induced gut microbiome changes and these response was differ between normal and MPE diet fed pigs. Overall, each group exhibited different major microbial composition in the gut. In conclusion, there were significant changes in the major microbial composition in response to high-density stress, and this variation was influenced by dietary treatment.